People living with HIV/AIDS (PLHA) in Thailand are increasingly encouraged to work in partnership with NGOs to improve access to disease prevention and treatment provision. This case study outlines the impact of this collaboration over a period of four years. PLHA have been directly involved in lobbying and advocacy, helping make ART more widely available, but also promoting prevention and treatment of opportunistic infections, focusing on the use of co-trimoxazole. Their involvement as co-providers in care has positively changed the attitude of health care staff towards HIV/AIDS patients. The study concludes that a coordinated collaboration between the public health system, NGOs and PLHA would have important spin-offs for both health care providers and PLHA themselves