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This paper focuses on mother to child transmission of HIV in the five most affected countries in Asia -- Cambodia, China, India, Myanmar, and Thailand. The technical background and lessons learned, however, are relevant for the rest of the region. It discusses risk factors, issues of diagnosis and treatment of pediatric AIDS and experiences of prevention in Asia and elsewhere. In particular it looks at issues of: comprehensive maternal and child health (MCH) services; voluntary counselling and testing (VCT); antiretroviral (ARV) prophylaxis; counselling and support for safe infant feeding; optimal obstetric practices. This document is intended as a technical resource and a basis for discussion and it is aimed at governments, NGOs and other stakeholders working in HIV prevention in Asia