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The present study examined how depressive symptoms change in late adolescence and whether reading disabilities (RD) affect the level or change of the symptoms. The sample consisted of 293 Finnish adolescents (150 girls, 143 boys; 58 with RD). Participants completed a screening test for reading and spelling skills in ninth grade (age 15), and a depression screening test three times during upper secondary education (ages 16–18). Longitudinal data were analysed using repeated measures ANOVA. Adolescents’ self-reported level of depressive symptoms increased in late adolescence ( p , 0.001). RD did not directly affect the level or change of depressive symptoms. Girls reported a greater increase in depressive symptoms than boys, and this interaction effect held especially for girls with RD.